cGMP Regulation

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eNOS Regulation

Regulation by PKG




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cGMP molecule

Cyclic GMP

Regulation

Created by Dr. Luis Agulló (last update on 12-6-2007)



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Regulation of the NO/cGMP system is not completely understood yet. Every enzyme of the pathway has a complex modulation of its activity. Probably the regulation best known is that of the endothelial nitric oxide synthase (eNOS, NOS II, NOS2). So as, a significant part of this site is focus on this protein. However, since this field continuous being very active it can be predicted that the regulation of several other enzymes would be revealed in brief. For instance, we will try to present here some of the new data about regulation of the soluble or NO-sensitive guanylyl cyclase (guanylate cyclase).





1. eNOS regulation:

1.1. Calcium

1.2. Co- and Post-translational modifications

1.3. Membrane association

1.4. Phosphorylation

2. NO availability: another type of regulation

3. Regulation of soluble guanylyl/guanylate cyclase:

3.1. Divalent cations and ATP

3.2. Phosphorylation

3.3. Membrane and protein association

4. Regulation of membrane guanylyl/guanylate cyclase:

5. Regulation of phosphodiesterase 5 (PDE5)

6. Pathway regulation by protein kinase G





We cannot completely guarantee the exactitude of all the information shown in these pages. We present here only a simplified view of the complex reality, and then we have to make sometimes a personal interpretation of the published data. In addition, undesirable errors can be introduced by the editors. So as, if anyone disagree with the information presented here or simply thinks that it is incorrect, please contact with us!. We would try to solve those questions as soon as possible. In any case, we encouragely suggest to consult the original sources of information. We show here many of the papers that have been used to make these pages.

In this part of the site we could not select only free access references. In those cases, a link to the abstract of the publication is shown.






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