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Created by Dr. Luis Agulló (last update on 12-6-2007)



Heme-independent Activators of Soluble Guanylyl/Guanylate Cyclase



BAY 58-2667

Potency: -

Membrane permeability: - / Solubility: - / MW: -

Comments: . The company does not easily donate the compound and it is not sold by any distributor yet. Surprisingly, BAY 58-2667 stimulated the heme-oxidized or heme-depleted purified enzyme almost 200-fold. This indicates that BAY 58-2667 may be able to substitute for the heme group or stabilize the heme-free conformation1.

1Stasch JP, Schmidt P, Alonso-Alija C, Apeler H, Dembowsky K, Haerter M, Heil M, Minuth T, Perzborn E, Pleiss U, Schramm M, Schroeder W, Schroder H, Stahl E, Steinke W, Wunder F. NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br J Pharmacol 2002;136:773.

CAUTION: -


HMR1766

Potency: EC50= 0.8-2 µM in vitro (vasorelaxation vessels); ED50= 3-10 mg/kg iv (blood pressure decrease)

Membrane permeability: - / Solubility: - / MW: -

Comments: Produced by Aventis Pharma Deutschland GmbH .

CAUTION: -


S3448

Potency: -

Membrane permeability: - / Solubility: - / MW: -

Comments: Produced by Aventis Pharma Deutschland GmbH.

CAUTION: -






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