Heme-independent Activators of Soluble Guanylyl/Guanylate Cyclase

BAY 58-2667

Potency: -

Membrane permeability: - / Solubility: - / MW: -

Comments: . The company does not easily donate the compound and it is not sold by any distributor yet. Surprisingly, BAY 58-2667 stimulated the heme-oxidized or heme-depleted purified enzyme almost 200-fold. This indicates that BAY 58-2667 may be able to substitute for the heme group or stabilize the heme-free conformation¹.

¹Stasch JP, Schmidt P, Alonso-Alija C, Apeler H, Dembowsky K, Haerter M, Heil M, Minuth T, Perzborn E, Pleiss U, Schramm M, Schroeder W, Schroder H, Stahl E, Steinke W, Wunder F. NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br J Pharmacol 2002;136:773.

CAUTION: -

HMR1766

Potency: EC₅₀= 0.8-2 µM in vitro (vasorelaxation vessels); ED₅₀= 3-10 mg/kg iv (blood pressure decrease)

Membrane permeability: - / Solubility: - / MW: -

Comments: Produced by Aventis Pharma Deutschland GmbH .

CAUTION: -

S3448

Potency: -

Membrane permeability: - / Solubility: - / MW: -

Comments: Produced by Aventis Pharma Deutschland GmbH.

CAUTION: -