Home (Regulation)

Regulation of the NO/cGMP system is not completely understood yet. Every enzyme of the pathway has a complex modulation of its activity. Probably the regulation best known is that of the endothelial nitric oxide synthase (eNOS, NOS II, NOS2). So as, a significant part of this site is focus on this protein. However, since this field continuous being very active it can be predicted that the regulation of several other enzymes would be revealed in brief. For instance, we will try to present here some of the new data about regulation of the soluble or NO-sensitive guanylyl cyclase (guanylate cyclase).

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1. eNOS regulation:

1.1. Calcium

1.2. Co- and Post-translational modifications

1.3. Membrane association

1.4. Phosphorylation

2. NO availability: another type of regulation

3. Regulation of soluble guanylyl/guanylate cyclase:

3.1. Divalent cations and ATP

3.2. Phosphorylation

3.3. Membrane and protein association

4. Regulation of membrane guanylyl/guanylate cyclase:

5. Regulation of phosphodiesterase 5 (PDE5)

6. Pathway regulation by protein kinase G

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